Technical Articles

LGR5, as a key receptor of the Wnt signaling pathway and a marker of cancer stem cells in multiple tumors, plays an important role in the initiation, progression, metastasis, and drug resistance of colorectal cancer, liver cancer, breast cancer, glioblastoma, and other tumors. Structural characterization, antibody screening, receptor interaction, and functional validation centered on LGR5 recombinant proteins have become important support for the development of LGR5-targeted antibodies, ADCs, bispecific antibodies, CAR-T, and other therapeutics.