Technical Articles

M-CSF

Raw264.7 cells: Unveiling the "Key Model" of Bone Resorption and Novel Therapeutic Targets for Diseases

2025-12-03

The Raw264.7 cell line is a murine-derived monocyte/macrophage lineage and serves as the gold standard in vitro model for studying osteoclast differentiation, function, and bone resorption mechanisms.

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Immunity/Inflamma
Raw264.7 cells
Osteoclast Differentiation
RANKL
M-CSF
Osteoporosis

M-CSF: The "Supreme Commander" of Macrophages and Its Double-Edged Sword Role in the Disease Battlefield

2025-11-24

M-CSF, or macrophage colony-stimulating factor, is a key regulator in the hematopoietic system that determines the fate of mononuclear macrophages. It is far more than just a "growth factor" for macrophages; it is the "supreme commander" of their survival, differentiation, and function.

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Immunity/Inflamma
M-CSF
macrophage colony-stimulating factor
CSF-1
macrophages
tumor-associated macrophages
osteoclasts

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