Technical Articles

MFR protein (Macrophage Fusion Receptor), a transmembrane protein playing a crucial role in the immune system, exhibits significant differences in structural features and functional mechanisms between animals and plants. In animals, MFR protein (also known as SIRPα, CD172a) is composed of multiple subunits. Its extracellular segment contains immunoglobulin-like domains, while its intracellular segment contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs).