Technical Articles

The MHC IIb molecule belongs to the non classical MHC class II subtype, and its gene localization, protein structure, and antigen presentation mechanism differ significantly from the classical MHC IIa molecule. These types of molecules (such as H2-O and H2-M in mice and HLA-DM and HLA-DO in humans) do not directly participate in the exogenous presentation of antigen peptides, but indirectly affect the activation and immune response intensity of CD4 ⁺ T cells by regulating the peptide loading, editing, and exchange processes of classical MHC-II molecules.