Technical Articles

MHC class II tetramer

Engineered MHC class II tetramers enhance the detection sensitivity of antigen-specific T cells by strengthening CD4 binding.

2025-05-12

T cells play a core role in cell-mediated immune responses by recognizing specific peptide antigens bound to MHC molecules. Fluorescently labeled peptide:MHC class I (pMHC I) tetramers are standard for identifying antigen-specific CD8⁺ T cells via flow cytometry. However, extending this technology to detect CD4⁺ T cells faces technical challenges.

View details

Immunity/Inflamma
MHC class II tetramer
MHC
T cell

Total 1

Go to