Technical Articles

This article focuses on the molecular characteristics and biological functions of matrix metalloproteinase-9 (MMP-9), systematically elaborating its molecular mechanism in the course of Parkinson's disease by cleaving β-dystroglycan, leading to aquaporin-4 depolarization and glymphatic system dysfunction, analyzing the pathological driving role of MMP-9 in neuroinflammation and neurodegeneration, and exploring the clinical significance of inhibiting MMP-9 as a potential target for enhancing glymphatic system function and neuroprotection.