Technical Articles

MPK-5 (mitogen activated protein kinase 5), as a core member of the MAPK family, is highly conserved in eukaryotes. It converts extracellular stimuli into intracellular responses through cascade signaling, regulating key processes such as cell proliferation, stress adaptation, and immune response.

MPK-5, also known as ERK5 (Extracellular Signal-Regulated Kinase 5), is a pivotal member of the MAPK family, distinguished by its conserved structure and functional versatility. This review systematically elucidates the molecular architecture of MPK-5, its signaling transduction mechanisms, dual roles in plant stress resistance and cancer regulation, and its therapeutic potential as a drug target, providing a theoretical foundation for cross-disciplinary research.