Technical Articles

MYD1 (Macrophage-Derived 1 protein), a member of the immunoglobulin superfamily, exhibits distinct structural features. Encoded by the SHPS1 gene, MYD1 comprises three functional domains: Extracellular domain: Three immunoglobulin-like V-type domains (IgV-IgV-IgC) enabling ligand recognition. Transmembrane domain: α-helical structure ensuring membrane localization. Intracellular domain: Immunoreceptor tyrosine-based inhibitory motif (ITIM) mediating signal transduction.