Technical Articles

Macrophage

Study on TNF-α signaling pathway and the therapeutic mechanisms of its inhibitors

2026-02-25

Tumor necrosis factor α (TNF-α) is a pleiotropic cytokine composed of 157 amino acids that functions as a homotrimer.

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Signaling Pathway
Mouse TNF-α Kit
Macrophage
Inflammation regulation

IL-6 signaling pathway: molecular mechanisms, biological functions, and disease associations

2026-02-06

Interleukin-6 is a pleiotropic cytokine secreted by various cells (such as macrophages, T cells, fibroblasts, etc.)

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Immunity/Inflamma
IL-6 protein
Macrophage
T cell

Tumor Necrosis Factor-α: Dual Mechanisms of Physiological and Pathological Roles and Detection Applications

2026-01-08

Tumor necrosis factor-α (TNF-α), as a key regulator of the immune system, is primarily secreted by activated macrophages and T lymphocytes

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Signaling Pathway
TNF-α/TNFR2 Kit
Immune system
Macrophage

SHPS1: The key "signal switch" for macrophages to regulate tumor immunity - from basic mechanisms to therapeutic breakthroughs

2025-04-28

SHPS1 (SHP substrate 1), also known as SIRPα (Signal Regulatory Protein α), is a member of the immunoglobulin superfamily and is mainly expressed on the surface of myeloid cells such as macrophages and dendritic cells. Its intracellular segment contains an immunoreceptor tyrosine inhibitory motif (ITIM), which can recruit tyrosine phosphatases SHP-1 and SHP-2 to regulate downstream signaling pathways.

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Cancer
SHPS1
Macrophage
Tumor
Recombinant Protein Expert
Nanjing Youai

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