Technical Articles

This article systematically elaborates on the expression characteristics of Nicotinamide N-methyltransferase (NNMT) in cancer-associated fibroblasts (CAFs) and its mechanism of depleting the methyl donor S-adenosylmethionine (SAM). It analyzes the molecular pathways by which NNMT drives CAFs differentiation and promotes tumor progression through epigenetic regulation, and explores the potential of targeting NNMT as a tumor stromal therapeutic strategy.