Technical Articles

Mouse normal small intestinal organoids, as a revolutionary model for studying intestinal epithelial biology in vitro, rely entirely on an exquisitely designed combination of cytokines for their miraculous growth and highly biomimetic structure. These minute signaling proteins function like a precise "conductor," orchestrating the self-renewal, differentiation, and tissue construction of intestinal stem cells, perfectly recapitulating the micro-physiological unit of the in vivo intestinal crypt-villus axis.