Technical Articles

Aberrant activation of the NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) inflammasome has been confirmed as a key pathogenic mechanism in various human diseases, including atherosclerosis (Duewell et al., 2010), gout (Martinon et al., 2006), multiple sclerosis (Inoue et al., 2012), Alzheimer's disease (Halle et al., 2008), and several malignancies (Kolb et al., 2014; Karki et al., 2017; Sekaran et al., 2024). The NLRP3 inflammasome is a cytosolic multi-protein complex composed of the pattern recognition receptor (PRR) NLRP3, the adapter protein ASC (apoptosis-associated speck-like protein containing a CARD), and the effector pro-caspase-1. Gene mutations in NLRP3 can cause Cryopyrin-Associated Periodic Syndromes (CAPS), further underscoring the importance of in-depth research into its regulatory mechanisms.