Technical Articles

This article focuses on the molecular characteristics and biological functions of NPC2 protein, systematically elaborating its core role in lysosomal cholesterol transport through a "hand-to-hand" mechanism that delivers free cholesterol to NPC1 protein, analyzing the crystal structure characteristics of NPC2 protein and the structural basis of its binding to sterol molecules, and exploring the molecular mechanism by which NPC2-mediated sterol molecule transport is coupled with proton transfer.