Technical Articles

NRG1 (neuroregulatory protein 1) belongs to the epidermal growth factor (EGF) family and is a type of protein molecule that produces multiple subtypes through selective splicing. Heregulin - β 1 (HRG - β 1, also known as Neu differentiation factor) is one of the most important biologically active forms of NRG1, which contains an EGF like functional domain in its structure and can specifically bind to and activate ErbB family receptors (especially ErbB3 and ErbB4).

Neuroregulatory protein 1 (NRG1) fusion, as a rare oncogenic driving mechanism, has received widespread attention in research on non-small cell lung cancer (NSCLC) in recent years. NRG1 fusion promotes tumor occurrence and development by abnormally activating the epidermal growth factor receptor (EGFR) family signaling pathway, providing a new direction for precision treatment of lung cancer