Technical Articles

This article systematically elucidates the physiological role of myelin basic protein (MBP) as a central nervous system-specific protein in maintaining myelin structural stability, and analyzes its clinical application value as a sensitive indicator and objective biochemical marker for brain injury in diseases such as acute traumatic brain injury, cerebral infarction, cerebral hemorrhage, and multiple sclerosis.

This article systematically elaborates on the clinical and basic research progress of MOG antibody-associated disease (MOGAD), presenting it as a novel inflammatory demyelinating disorder of the central nervous system distinct from multiple sclerosis and neuromyelitis optica spectrum disorders. It explores the molecular basis and pathogenesis of MOGAD, analyzes its age-dependent clinical manifestations, imaging features, and treatment strategies.

This article systematically elaborates on the molecular basis of MOG as a myelin component in the central nervous system and the demyelination process mediated by its autoantibodies, focusing on the pathological mechanisms and clinical features of MOG antibody-associated disease (MOGAD). It also analyzes the disease's incidence across different age groups, the diversity of clinical manifestations, and the patterns of recurrence.

Based on the challenges in the clinical treatment of osteoarthritis (OA), this article systematically elaborates on the key role of nerve growth factor β (β-NGF) in the occurrence and transmission of OA pain and its research progress as a novel therapeutic target, while analyzing the efficacy and safety challenges of NGF-targeted therapy.

This article systematically elaborates on the structural characteristics and immunogenicity of the myelin oligodendrocyte glycoprotein (MOG), the pathogenic mechanisms of MOG antibodies, and the historical evolution of detection methods for MOG antibody-associated disease (MOG-AD). It analyzes the diverse clinical phenotypes and imaging features of the disease across different age groups and discusses its treatment principles and prognosis.

This article systematically elaborates on the molecular basis and clinical characteristics of myelin oligodendrocyte glycoprotein immunoglobulin G antibody-associated disease (MOGAD) as an independent disease entity, analyzes its key differences from multiple sclerosis and neuromyelitis optica spectrum disorders, and introduces the diverse clinical manifestations, diagnostic points, and treatment strategies of MOGAD in different age groups.

Stem cell biology is a core research focus in the fields of regenerative medicine and tissue engineering.

Neurons and neuroglial cells are the basic units that constitute the structure and function of the nervous system.

PCSK9 is primarily synthesized and secreted by the liver as a serine protease, playing a crucial role in maintaining cholesterol homeostasis. PCSK9 elevates LDL-C levels by inhibiting circulating LDLR, competitively binding to LDLR on the surface of hepatocytes to form a PCSK9/LDLR complex. This complex is then transported into the cell via vesicles and degraded by lysosomes, leading to increased plasma LDL-C levels.

The neuroprotective effects of acupuncture are closely related to changes in various signaling pathways, and accumulating evidence suggests that endogenous biological mediators such as members of the neurotrophic protein family are involved.