Technical Articles

Based on the challenges in the clinical treatment of osteoarthritis (OA), this article systematically elaborates on the key role of nerve growth factor β (β-NGF) in the occurrence and transmission of OA pain and its research progress as a novel therapeutic target, while analyzing the efficacy and safety challenges of NGF-targeted therapy.

This article systematically elaborates on the structural characteristics and immunogenicity of the myelin oligodendrocyte glycoprotein (MOG), the pathogenic mechanisms of MOG antibodies, and the historical evolution of detection methods for MOG antibody-associated disease (MOG-AD). It analyzes the diverse clinical phenotypes and imaging features of the disease across different age groups and discusses its treatment principles and prognosis.

This article systematically elaborates on the molecular basis and clinical characteristics of myelin oligodendrocyte glycoprotein immunoglobulin G antibody-associated disease (MOGAD) as an independent disease entity, analyzes its key differences from multiple sclerosis and neuromyelitis optica spectrum disorders, and introduces the diverse clinical manifestations, diagnostic points, and treatment strategies of MOGAD in different age groups.

Stem cell biology is a core research focus in the fields of regenerative medicine and tissue engineering.

Neurons and neuroglial cells are the basic units that constitute the structure and function of the nervous system.

PCSK9 is primarily synthesized and secreted by the liver as a serine protease, playing a crucial role in maintaining cholesterol homeostasis. PCSK9 elevates LDL-C levels by inhibiting circulating LDLR, competitively binding to LDLR on the surface of hepatocytes to form a PCSK9/LDLR complex. This complex is then transported into the cell via vesicles and degraded by lysosomes, leading to increased plasma LDL-C levels.

The neuroprotective effects of acupuncture are closely related to changes in various signaling pathways, and accumulating evidence suggests that endogenous biological mediators such as members of the neurotrophic protein family are involved.

Myelin basic protein is a protein specific to the central nervous system, localized on the cytoplasmic face of the myelin membrane, and tightly bound to myelin lipids, playing a key role in maintaining the structural stability and functional integrity of myelin.

Perioperative neurocognitive disorders (PND) refer to newly developed cognitive impairment or worsening of pre-existing cognitive function within 12 months before and after surgery, and are one of the most common complications in elderly surgical patients.

Transcriptional memory refers to the phenomenon where certain genes exhibit a faster and stronger response to a secondary stimulus after an initial exposure to signaling molecules.