Technical Articles

Organoids have unique value in analyzing epithelial immune cell interactions and exploring the role of the immune system in the tumor microenvironment. In the research of tumor immunity, organoids have broken through the limitations of traditional models - they not only overcome the problem of lack of heterogeneity in tumor cell lines, but also solve the deficiency of xenograft models that cannot reproduce the human immune system, providing a new tool for the analysis of tumor immune mechanisms and the development of immunotherapy

In recent years, significant progress has been made in organoid technology, and normal and tumor derived organoids (such as intestines, liver, breast, brain, skin, etc.) have been successfully constructed. Although there are commonalities in the construction methods of organoids from different tissue sources, optimizing the composition of the culture medium and culture conditions remains the key to determining the success or failure of cultivation.