Technical Articles

Osteoarthritis is a common degenerative joint disease characterized by pathological features such as joint cartilage degeneration, subchondral bone sclerosis, and synovial inflammation.

Temporomandibular joint osteoarthritis is a chronic disease characterized by degenerative changes in articular cartilage, subchondral bone resorption, and extracellular matrix damage, with excessive mechanical stress considered a key pathogenic factor in its development and progression.

In the intricate cellular signaling network of the human body, there exists a family of proteins known as fibroblast growth factors, which act as precise messengers, regulating cell growth, differentiation, and repair.

Osteoarthritis, as a common degenerative joint disease, is characterized by abnormal angiogenesis of subchondral bone and vascular invasion into avascular joint cartilage tissue in its early stages. This process not only accelerates joint cartilage degeneration, but also leads to joint pain caused by nerve growth.