Technical Articles

PDGFR-α

PDGF-AA protein: The "Architect" of the Cellular World, Its Central Role in Repair, Fibrosis, and Tumors

2025-12-05

PDGF-AA is a unique homodimeric member of the platelet-derived growth factor family, renowned for its high-specificity affinity for the PDGFR-α receptor. As a potent mitogen and chemotactic factor, it plays a central role in embryonic development, tissue repair, and vascular homeostasis.

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Cancer
PDGF-AA
Platelet-Derived Growth Factor-AA
PDGFR-α
Fibrosis
Idiopathic Pulmonary Fibrosis (IPF)

PDGF-AA: The "Architect" and "Engineer" of the Cellular World, How It Drives Repair and Disease

2025-11-25

PDGF-AA is a key member of the platelet-derived growth factor family, serving as a critical signaling protein that plays a central role in cell growth, migration, and survival.

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Cancer
PDGF-AA
Platelet-derived growth factor
PDGFR-α
Cell proliferation
Cell migration.

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