Technical Articles

Based on the clinical practice of CD19 CAR-T cell therapy, this article systematically elucidates the core mechanisms of antigen escape leading to relapse, analyzes the molecular characteristics and expression patterns of CD22 as another key surface antigen in the B-cell lineage, explores the value of CD22-targeted therapy and CD19/CD22 dual-target strategies in overcoming resistance, and introduces the detection application of fluorescent-labeled recombinant proteins.