Technical Articles

The MMR system plays a crucial role in maintaining genomic stability. During DNA replication or recombination, errors such as base mismatches, small-scale base deletions, or insertions are inevitable. The MMR system, like a meticulous "proofreader," can accurately identify these errors and initiate the repair process. It mainly relies on the coordinated work of proteins encoded by key genes such as MLH1, PMS2, MSH2, and MSH6.