Technical Articles
PROTAC Technology
Mechanism study, molecular design, and TR-FRET detection application of PROTAC-mediated BTK degradation
In 2001, the concept of PROTAC was first proposed, which involves using bifunctional ligands to specifically bind to target proteins while recruiting E3 ligases for ubiquitination, ultimately leading to the degradation of the target proteins.
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- Drug Research
- BTK/CRBN
- TR-FRET Technology
- PROTAC Technology
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