Technical Articles

Platelet toxicity

Targeted protein degradation therapy for BCL-XL: Selective inhibition of tumor growth and strategies to mitigate platelet toxicity

2026-01-19

BCL-XL is a crucial anti-apoptotic member of the B-cell lymphoma-2 (BCL-2) protein family, which is overexpressed in various tumor cells and promotes tumor cell survival and proliferation by inhibiting the apoptosis process.

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Cancer
BCL-XL/VHL PROTAC Kit
Inhibition of tumor growth
Platelet toxicity

靶向BCL-XL的VHL依赖性PROTAC降解剂：克服血小板毒性的创新策略与试剂盒开发

VHL-dependent PROTAC degraders targeting BCL-XL: Innovative strategies to overcome platelet toxicity and development of reagent kits

2026-01-05

BCL-XL is highly expressed in various tumor cells, promoting their survival and drug resistance.

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Cancer
VAV1/CRBN PROTAC Kit
Platelet toxicity
Protein ligand

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