Technical Articles

This article focuses on the molecular characteristics and biological functions of R-Spondin 1 (RSPO1), systematically elaborating its domain composition as a core member of the R-spondin family, as well as its molecular mechanism of enhancing the Wnt/β-catenin signaling pathway by binding to the LGR4/5 receptors through its furin-like domain and neutralizing RNF43/ZNRF3-mediated ubiquitination degradation of Frizzled receptors. It also analyzes its critical roles in organ development, epithelial stem cell maintenance, and tumorigenesis.

This article focuses on the molecular characteristics and biological functions of R-Spondin 1 (RSPO1), systematically elaborating its domain composition as a core member of the R-spondin family. It analyzes the molecular mechanism by which RSPO1 enhances the Wnt/β-catenin signaling pathway through its furin-like domain binding to LGR4/5 receptors and neutralizing RNF43/ZNRF3-mediated ubiquitination degradation of Frizzled receptors.