Technical Articles

ROR1 (receptor tyrosine kinase like orphan receptor 1) belongs to the receptor tyrosine kinase like orphan receptor subfamily of the receptor tyrosine kinases (RTKs) superfamily, named after its unknown ligand at the time of initial discovery. Later, it was confirmed that it plays a key role in regulating cell communication, proliferation, differentiation, and survival by binding to Wnt family proteins to activate signaling pathways.

ROR1, an acronym for Receptor Tyrosine Kinase-like Orphan Receptor 1, is a transmembrane protein belonging to the ROR receptor family. In recent years, ROR1 has emerged as a focal point in the field of biomedicine due to its high expression in various malignancies, positioning it as a promising new drug target with broad-spectrum anticancer potential.