Technical Articles

RSPO1(21-146)

R-Spondin 1(21-146)：Wnt通路的"超级增强器"，在再生医学与疾病中的核心作用

R-Spondin 1(21-146): The "super-enhancer" of the Wnt pathway, its pivotal role in regenerative medicine and disease

2025-11-25

R-Spondin 1(21-146) is the core active fragment of the R-Spondin 1 protein, designed to efficiently and stably amplify the Wnt signaling pathway. As a "catalyst" for tissue regeneration and stem cell maintenance, it plays a key role in intestinal health, sexual development, and disease models.

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Signaling Pathway
R-Spondin 1
RSPO1(21-146)
Wnt/β-catenin signaling pathway
LGR5
ZNRF3/RNF43
Organoid.

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