Technical Articles

RSPO3 Protein

Structural characteristics and biological functions of RSPO3 protein

2026-04-20

The RSPO3 protein is a member of the R-spondin protein family, which includes four members: RSPO1, RSPO2, RSPO3, and RSPO4. The RSPO3 protein consists of approximately 270 amino acids, has a molecular weight of about 30 kilodaltons, and is a secreted glycoprotein.

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Stem Cells
RSPO3 Protein
Signal Transduction
Embryonic Development

RSPO3 protein: The "super-enhancer" of the Wnt pathway, a central hub in development, cancer, and metabolism

2025-12-05

RSPO3 (R-spondin 3) protein is a potent secreted member of the R-spondin family, serving as a core co-activator and amplifier of the Wnt/β-catenin signaling pathway, playing a decisive role in embryonic development, tissue homeostasis, and disease progression.

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Signaling Pathway
RSPO3 protein
R-spondin 3
Wnt/β-catenin signaling pathway
ZNRF3/RNF43

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