Technical Articles

Based on a landmark study employing proteomics and laser capture microdissection, this article systematically elucidates the phenomenon of elevated nicotinamide N-methyltransferase (NNMT) expression in cancer-associated fibroblasts (CAFs) of high-grade serous ovarian cancer and other solid tumors. It analyzes the molecular mechanism by which NNMT drives the CAF phenotype and pro-tumor microenvironment through depletion of the methyl donor SAM and reduction of histone methylation, while exploring the clinical value of NNMT as a prognostic biomarker and therapeutic target.