Technical Articles

EPO is a four-helix-bundle glycoprotein hormone acting through the EPOR-JAK2/STAT5 axis. This article explains erythroid development, glycosylation-driven molecular-weight heterogeneity and non-hematopoietic activities in vascular and neural research

A practical guide to recombinant mouse IL-2 in T cell expansion and ex vivo culture: dose setup, CD25/STAT5 readouts, common culture pitfalls and how to keep expansion reproducible.

Mouse IL-2 signals through CD25/CD122/gamma-c to activate JAK/STAT5, supporting T cell growth and Treg biology. This article explains its receptor mechanism, activity assays and immune experiment applications.

A core member of the class I cytokine family, IL-2 activates the JAK1/JAK3-STAT5 pathway through its ternary receptor complex. This article reviews receptor composition, signaling hierarchy, affinity stratification, and immunoregulatory research tool

Once defined by lactation biology, the prolactin receptor PRLR has re-entered targeted research three decades later on the strength of high expression profiles in luminal breast cancer. This article unpacks the receptor's dual identity and translatio

A systematic review of the prolactin receptor (PRLR), a class I cytokine receptor family member that transmits prolactin signals via the JAK2-STAT5 pathway: receptor structure and isoforms, signaling hierarchy, physiological functions, and the toolki