Technical Articles

Siglec-2 (also known as CD22) is a member of the sialic acid binding immunoglobulin like lectin (Siglec) receptor family, primarily expressed on the surface of B cells. As an inhibitory receptor, it regulates immune response by recognizing sialylated polysaccharides on the cell surface.

Siglec-2 (also known as CD22) is a highly conserved member of the sialic acid recognizing immunoglobulin like lectin (Siglec) family, mainly expressed on the surface of B lymphocytes. It participates in the precise regulation of B cell activation, proliferation, and tolerance by recognizing sialic acid modified sugar chain structures.