Technical Articles

The sialic acid binding immunoglobulin like lectin (Siglec) family is a type of transmembrane receptor that recognizes sialic acid glycosaminoglycans and plays an important role in immune suppression in the tumor microenvironment. This family contains 15 human derived and 9 mouse derived molecules, which are classified into sequence conserved and CD33 related rapidly evolving types based on evolutionary conservation. Siglec-3 (CD33) belongs to the CD33 related subfamily and is one of the focuses of tumor immune research.