Technical Articles

Siglec-7 belongs to the CD33 related rapid evolution subfamily and is a type I transmembrane protein. Its extracellular domain contains one V-set immunoglobulin domain responsible for sialic acid binding and two C2 set immunoglobulin domains, while its intracellular domain contains typical immune receptor tyrosine inhibitory motif (ITIM) and immune receptor switching motif (ITSM).