Technical Articles

Leukemia inhibitory factor (LIF) is an important member of the interleukin-6 cytokine family. Its encoded gene is located in a specific region of the human chromosome and forms a complex by binding to the LIF receptor (LIFR) and gp130 co receptor on the cell membrane, activating downstream signaling pathways such as JAK-STAT, MAPK, and PI3K, and participating in various biological processes such as cell proliferation, differentiation, and survival.