Technical Articles

Solid tumor

Advances in Novel TCR Therapies Targeting KRAS G12V Mutation and Prospects for Protein Degradation Strategies

2026-01-23

The KRAS gene is one of the most commonly mutated driver genes in various solid tumors, with the G12V mutation being the second most frequent subtype at codon 12 after G12D, frequently occurring in malignancies such as pancreatic cancer and colorectal cancer.

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Cancer
KRAS[G12V]/CRBN PROTAC Kit
Solid tumor
Protein degradation

Research Progress on TCE and PROTAC Technologies Targeting KRAS[G12V]

2026-01-12

KRAS[G12V], as one of the key mutation types at codon 12 of the KRAS gene, exhibits a significant distribution in various solid tumors.

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Cancer
KRAS[G12V]/CRBN PROTAC Kit
Solid tumor
T cell engager

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