Technical Articles

TGF-β receptor

Novel 7-Azaindole Small Molecule Inhibitors Targeting ActRIIB: A New Strategy to Tackle Cancer Cachexia

2025-10-28

ActRIIB (Activin Type IIB Receptor) and ACTRIIA (Activin Type IIA Receptor) are structurally similar transmembrane receptors belonging to the TGF-β receptor superfamily. They collectively function to receive extracellular "growth regulatory signals," yet exhibit key distinctions in their physiological roles and their value as drug targets.

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Drug Research
ActRIIB
ACTRIIA
TGF-β receptor
UA BIOSCIENCE
UA Protein

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