Technical Articles

With the continuous improvement of global living standards, the incidence of obesity and overweight continues to rise, posing a severe public health challenge. Currently, there remains a lack of effective treatments for overnutrition-induced obesity, which involves complex metabolic and immune regulatory mechanisms. Notably, obesity is often accompanied by a low-grade chronic inflammatory state, further triggering metabolic syndrome. However, the specific molecular mechanisms underlying this process remain unclear.

EphA2 is a tyrosine kinase receptor, so using tyrosine kinase inhibitors (TKIs) to inhibit the kinase activity of EphA2 is a potential therapeutic strategy. The multiple signaling pathways and non-kinase-dependent functions of EphA2 make targeted therapy complicated, and appropriate treatment methods need to be selected according to different tumor types and environments.