Technical Articles
Temporomandibular Joint Osteoarthritis
Study of BRD4-targeting PROTAC degraders based on TR-FRET technology in temporomandibular joint osteoarthritis
The essence of temporomandibular joint osteoarthritis is a degenerative joint disorder, with excessive mechanical stress being a significant cause of the disease. Thinning of cartilage, subchondral bone resorption, and extracellular matrix damage are the primary pathological changes induced by excessive mechanical stress.
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- Immunity/Inflamma
- Degenerative Joint Disease
- Temporomandibular Joint Osteoarthritis
- BRD4
The role and mechanism of BRD4 signaling pathway in stress-induced osteoarthritis and targeted degradation therapy strategies
Temporomandibular joint osteoarthritis is a chronic disease characterized by degenerative changes in articular cartilage, subchondral bone resorption, and extracellular matrix damage, with excessive mechanical stress considered a key pathogenic factor in its development and progression.
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- Immunity/Inflamma
- BRD4/CRBN PROTAC Kit
- Osteoarthritis
- Temporomandibular joint osteoarthritis
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