Technical Articles

基于TR-FRET技术的BRD4靶向PROTAC降解剂在颞下颌关节骨关节炎中的研究
Study of BRD4-targeting PROTAC degraders based on TR-FRET technology in temporomandibular joint osteoarthritis
发布时间 2026-04-15
The essence of temporomandibular joint osteoarthritis is a degenerative joint disorder, with excessive mechanical stress being a significant cause of the disease. Thinning of cartilage, subchondral bone resorption, and extracellular matrix damage are the primary pathological changes induced by excessive mechanical stress.
View details
  • Immunity/Inflamma
  • Degenerative Joint Disease
  • Temporomandibular Joint Osteoarthritis
  • BRD4
BRD4信号通路在应力诱导骨关节炎中的作用机制与靶向降解治疗策略
The role and mechanism of BRD4 signaling pathway in stress-induced osteoarthritis and targeted degradation therapy strategies
发布时间 2026-01-21
Temporomandibular joint osteoarthritis is a chronic disease characterized by degenerative changes in articular cartilage, subchondral bone resorption, and extracellular matrix damage, with excessive mechanical stress considered a key pathogenic factor in its development and progression.
View details
  • Immunity/Inflamma
  • BRD4/CRBN PROTAC Kit
  • Osteoarthritis
  • Temporomandibular joint osteoarthritis
Total 2
  • 1
Go to