Technical Articles

The important role of EphA2 in tumor biology makes it a promising therapeutic target, and ongoing efforts to target EphA2 in the clinic may provide a valuable new weapon in the fight against cancer. Future efforts include continued in-depth understanding of EphA2-Ephrin A1 signaling and precise elucidation of crosstalk with other oncogenic pathways. Completed clinical studies and new biological findings provide clues for the development of the next generation of EphA2-targeted therapies: (I) the focus should be on improving efficacy and selectivity while preventing off-target side effects; and (II) combination with other therapies may be helpful.