Technical Articles

Tumor immunology

ITPRIPL1 as a novel inhibitory ligand of CD3ε in tumor immune escape: Mechanisms and targeting strategies

2026-02-10

The advent of tumor immunotherapy, particularly immune checkpoint blockade therapy, has significantly transformed the treatment landscape for various malignant tumors.

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Cancer
CD3E&CD3D
Tumor immunology
Malignant tumor

The regulatory role of STUB1 ubiquitin ligase in interferon-γ receptor stability and its mechanism in tumor immunity

2026-02-06

Interferon-gamma is a key effector cytokine secreted by cytotoxic T lymphocytes and natural killer cells, playing multiple roles in anti-tumor immune responses.

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Cancer
IFN-gamma R1/IFNGR1 Fc Chimera protein
Tumor immunology
T lymphocyte

Targeting TGF-β2: Reshaping the Immunosuppressive Tumor Microenvironment to Enhance Anti-Tumor Immunity

2026-01-30

Pancreatic ductal adenocarcinoma is one of the most malignant solid tumors, with an extremely poor prognosis and a poor response to various treatment modalities, including immune checkpoint inhibitors.

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Cancer
TGF-β2 protein
Tumor microenvironment
Tumor immunology

The Dual Role of IL-10 Signaling in Tumor Immunotherapy and Precision Research Strategies

2026-01-19

Interleukin-10 and its receptors play a complex dual role in the tumor immune microenvironment. Traditionally, IL-10 is known for its ability to suppress antigen-presenting cell activation and the production of pro-inflammatory cytokines.

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Cancer
IL10/IL10RA Kit
Tumor immunology
Tumor microenvironment

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