Technical Articles

Tumor necrosis factor (TNF) plays a complex dual role in the intestine: on one hand, it is a key mediator of host defense and tissue repair

Tumor necrosis factor receptor 1 (TNFR1, also known as TNFRSF1A, CD120a, or p55) is an important member of the tumor necrosis factor receptor superfamily.

BAFF, fully known as B-cell Activating Factor, also referred to as BLyS and TNFSF13B, is a member of the tumor necrosis factor superfamily. As a crucial type II transmembrane protein, BAFF is primarily secreted by myeloid cells and serves as a key regulator for the survival, maturation, and activation of B lymphocytes. Since its discovery, BAFF has become a central target for research and drug development in autoimmune diseases, particularly those involving B cells.

B-cell activating factor (BAFF, also known as BLyS or TNFSF13B), a member of the tumor necrosis factor superfamily, is a central regulator of B lymphocyte survival, maturation, and function. Dysregulation of its signaling pathway is closely associated with the pathogenesis and progression of various autoimmune diseases. This article aims to systematically elucidate the biological functions, signaling pathways, pathological roles, and research progress in targeted therapies of BAFF, providing peers with an overview focused on molecular mechanisms and research frontiers.

In the battleground of immunotherapy, members of the tumor necrosis factor (TNF) family shine as "superstars" in combating tumors and inflammation. Serving as the immune system's "superheroes," TNF family proteins play pivotal roles in inflammatory responses and tumor immunity.