Technical Articles
UA010194
Recombinant Human CD40 Fc Chimera: How the Immune Switch Is Opened at the Molecular Level
2026-10-16CD40 is a TNF receptor family costimulatory molecule on B cells and dendritic cells. This article explains its trimerization-driven signaling, CD40L engagement and why the Fc chimera format is the standard reagent for binding studies.
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- Immunity/Inflamma
- CD40
- TNFRSF5
- CD40L
- Fc chimera
- costimulation
- B cell
- dendritic cell
- TRAF
- UA010194
CD40 Agonism in Immuno-Oncology: Why Expectations Stay High
2026-10-16This article reviews CD40 agonism in immuno-oncology research: licensing dendritic cells, reversing the cold tumor phenotype, the safety trade-offs of systemic agonism and what standardized CD40 reagents contribute to preclinical workflows.
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- Immunity/Inflamma
- CD40 agonist
- immuno-oncology
- dendritic cell licensing
- cold tumor
- combination therapy
- UA010194
Working with CD40 Fc Chimera: Avoiding Fc-Mediated Interference in B Cell and DC Activation Assays
2026-10-16A practical guide to recombinant CD40/TNFRSF5 Fc chimera: choosing Fc controls, plate-coating versus soluble formats, crosslinking strategy and how to separate CD40-specific signaling from Fc-mediated background.
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- Immunity/Inflamma
- CD40 Fc chimera
- Fc interference
- crosslinking
- B cell activation
- dendritic cell
- co-culture
- UA010194
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