Technical Articles
UA040004
EPO in Translation: From Anemia Therapy to Tissue Protection and Long-Acting Formats
2026-10-15This article reviews the EPO/EPOR pathway in drug development: early recombinant erythropoietins, long-acting formats, tissue-protection directions and what these experiences teach about preclinical study design.
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- Cancer
- EPO target
- erythropoietin
- long-acting format
- tissue protection
- hypoxia
- translational research
- UA040004
Working with Recombinant Human EPO: Troubleshooting Cell-Proliferation Activity Readouts
2026-10-15A practical guide to EPO-dependent proliferation assays (TF-1): reconstitution, aliquoting, diluent choice, carrier protein, cell state and dose-response design, with a checklist for inconsistent EC50 values.
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- Cancer
- EPO cell treatment
- TF-1
- proliferation assay
- reconstitution
- carrier protein
- EC50
- troubleshooting
- UA040004
Recombinant Human EPO: Why a Hematopoietic Hormone Keeps Showing Up in Vascular and Neural Research
2026-10-15EPO is a four-helix-bundle glycoprotein hormone acting through the EPOR-JAK2/STAT5 axis. This article explains erythroid development, glycosylation-driven molecular-weight heterogeneity and non-hematopoietic activities in vascular and neural research
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- Cancer
- EPO
- EPOR
- JAK2
- STAT5
- erythroid progenitor
- glycosylation
- CHO expression
- neuroprotection
- UA040004
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