Technical Articles

VAV1/CRBN PROTAC Kit

Biological functions of VAV1, disease associations, and targeted therapeutic strategies: focusing on PROTAC technology

2026-01-16

VAV1 (Vav Guanine Nucleotide Exchange Factor 1) is an important intracellular signaling protein, belonging to the guanine nucleotide exchange factor (GEF) family.

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Signaling Pathway
VAV1/CRBN PROTAC Kit
Signal transduction protein
T cell

The CRBN E3 ligase in targeted protein degradation technology and its application advantages

2026-01-05

Targeted Protein Degradation (TPD) technology is a hot field in recent drug development.

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Drug Research
VAV1/CRBN PROTAC Kit
Targeted protein degradation
E3 ligase

靶向BCL-XL的VHL依赖性PROTAC降解剂：克服血小板毒性的创新策略与试剂盒开发

VHL-dependent PROTAC degraders targeting BCL-XL: Innovative strategies to overcome platelet toxicity and development of reagent kits

2026-01-05

BCL-XL is highly expressed in various tumor cells, promoting their survival and drug resistance.

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Cancer
VAV1/CRBN PROTAC Kit
Platelet toxicity
Protein ligand

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