Technical Articles

This article focuses on the molecular characteristics and biological functions of VEGF165, systematically elaborating on its structural features as the predominant subtype of the vascular endothelial growth factor family and its mechanisms in promoting angiogenesis. It analyzes its central role in the development and progression of solid tumors and explores its clinical application value as a broad-spectrum tumor biomarker in early screening, efficacy evaluation, and recurrence monitoring.

This article systematically elaborates on the molecular characteristics and biological functions of VEGF165, focusing on its structural features as the predominant isoform of the vascular endothelial growth factor family, its mechanisms in promoting angiogenesis, and its diverse physiological roles across multiple systems. It also analyzes its central role in tumor angiogenesis and its clinical application value as a broad-spectrum tumor marker.

In 1989, researchers collectively named the substance that promotes vascular endothelial cell permeability as vascular endothelial growth factor. The initial functions of VEGF primarily included promoting the proliferation of vascular endothelial cells, angiogenesis, and increasing vascular permeability.