Technical Articles

IdeZ (Immunoglobulin G-degrading enzyme of Streptococcus zooepidemicus) is a bacterial protease that specifically cleaves IgG antibodies. In recent years, it has attracted much attention for its unique applications in antibody engineering, gene therapy, and immunological research. This article systematically reviews the molecular properties, mechanisms of action, application progress, and future challenges of IdeZ, with a focus on exploring its potential in overcoming neutralizing antibody barriers in AAV gene therapy, constructing multispecific antibodies, and treating autoimmune diseases

Folate binding protein antibodies are specific antibodies prepared against targets such as folate binding protein (FBP) or folate receptor alpha (FRα), which are of great significance in medical research and clinical diagnosis.

Heparin-binding protein (HBP) is a multifunctional protein secreted by neutrophils. It has attracted much attention due to its important role in immune response, inflammation regulation and coagulation function.