Technical Articles

Erythropoietin is a sialic acid glycoprotein with a molecular weight of approximately 30-34 kDa, traditionally defined as a classic hematopoietic growth factor specifically produced by the kidneys, which acts in a hormonal manner on the bone marrow to dominate erythropoiesis.

In recent years, studies have found that abnormal expression of the anti-aging gene α - Klotho (KL) is closely associated with CKD anemia. Its high expression in the kidneys makes it a key molecule connecting kidney function and hematopoietic regulation. Although multiple clinical studies have confirmed a significant decrease in alpha Klotho levels in CKD patients with anemia, the regulatory network behind this molecular change still needs to be further elucidated.

Asialoglycoprotein receptor 1 (ASGR1 for short), which shows great application prospects in the regulation of cholesterol metabolism and the treatment of cardiovascular diseases.