Technical Articles
gp130
What Is CNTF: Neuroprotective Mechanisms, Retinal Evidence and Activity Assays
2026-10-15CNTF is an IL-6 family neurotrophic cytokine acting through CNTFR/gp130/LIFR. This article covers its neuroprotective mechanisms, retinal ganglion cell evidence and activity determination with recombinant rat CNTF.
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- Cell Biology
- CNTF
- ciliary neurotrophic factor
- CNTFR
- gp130
- neuroprotection
- retinal ganglion cell
- activity assay
- UA040187
Working with Recombinant Mouse IL-6: Cell Stimulation, Standards and Troubleshooting
2026-10-13A practical guide to recombinant mouse IL-6 as a research tool: using it as a cell stimulation source and immunoassay standard, potency considerations and troubleshooting weak STAT3 readouts.
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- Immunity/Inflamma
- mouse IL-6
- IL-6 standard
- cell stimulation
- gp130
- STAT3
- assay troubleshooting
- recombinant cytokine
- UA040155
Recombinant Mouse IL-6: One Cytokine Across Acute-Phase Response and Chronic Inflammation
2026-10-13Mouse IL-6 drives the acute-phase response through classic signaling and sustains chronic inflammation via trans-signaling. This article breaks down receptor assembly, the JAK/STAT3 axis and common experimental readouts.
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- Immunity/Inflamma
- IL-6
- interleukin 6
- mouse IL-6
- gp130
- IL-6R
- JAK
- STAT3
- trans-signaling
- acute-phase response
- UA040155
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