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LIF Protein: A Versatile Cytokine—From Embryo Implantation to Neural Repair and Cancer Battle

2025-11-24

LIF, short for Leukemia Inhibitory Factor, belongs to the interleukin-6 cytokine family. It was named for its initial discovery of inhibiting the proliferation of murine leukemia cell lines and inducing their differentiation. However, subsequent research has revealed the extreme functional diversity of LIF, making it a key pleiotropic cytokine.

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Cancer
LIF
leukemia inhibitory factor
cytokine
embryo implantation
endometrial receptivity
infertility.

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