Technical Articles

Chronic rhinosinusitis with nasal polyps (CRSwNP) is an upper respiratory disease characterized by chronic inflammation of the sinus mucosa and the formation of polyps.

Signal transducer and activator of transcription 6 is a key member of the JAK-STAT signaling pathway family, serving as a central effector for interleukin-4 and interleukin-13 signaling, and plays a decisive role in allergic responses, parasitic immunity, and shaping specific tumor microenvironments.

The full name of TNF-α is tumor necrosis factor-α, primarily produced by activated immune cells such as macrophages and T cells. As a pleiotropic cytokine, it plays a dual role in the human body: both as a defender against infections and as a promoter of tissue damage.

Interleukin-33 (IL-33) is a key "alarmin" cytokine that plays a central role in immune defense and tissue homeostasis.

Granulocyte macrophage colony-stimulating factor (GM-CSF) is a glycoprotein initially identified as a hematopoietic growth factor that promotes the differentiation of bone marrow progenitor cells into granulocytes and macrophages. With the deepening of research, it has been found that its biological function goes far beyond hematopoietic function.

文档 图片 88/1000 实时翻译 文档图片88/1000实时翻译划译在复杂的炎症调节网络中，白细胞介素-8（IL-8）作为CXC趋化因子家族的重要成员，通过特异性趋化中性粒细胞参与炎症反应，在宿主防御和炎症性疾病的发生发展中起着核心作用。 划译 In the complex inflammatory regulatory network, interleukin-8 (IL-8), as an important member of the CXC chemokine family, participates in the inflammatory response by specifically chemotactic neutrophils and plays a central role in host defense and the occurrence and development of inflammatory diseases.

Interleukin-6 (IL-6) is a multifunctional cytokine composed of 174 amino acids, with a molecular weight of approximately 21-28 kDa, and is a typical representative of the IL-6 family of cytokines.

In the field of tumor immunology, the complex regulatory network of inflammation and immune response has always been a research hotspot. Interleukin-1 β (IL-1 β), as a key pro-inflammatory cytokine, plays a "double agent" role in the interaction between the immune system and the tumor microenvironment. On the one hand, IL-1 β activates anti-tumor immune mechanisms by inducing acute inflammatory responses, directly or indirectly killing cancer cells; On the other hand, under specific conditions, it may accelerate tumor progression by promoting angiogenesis, tumor cell proliferation, and other pathways. The duality of this function makes it a highly controversial and promising target in tumor immunotherapy research.