Technical Articles

The Klotho protein, encoded by the KL gene, is a transmembrane protein originally identified in mice. Its nomenclature derives from Clotho, the Fate goddess in Greek mythology who spins the thread of life. Emerging research has revealed that Klotho serves as a pleiotropic protein critically involved in lifespan regulation and associated with multiple age-related pathologies, making it a subject of intense investigation in geroscience.